![]() ![]() Cerebral venous hypertension due to incompetence of the internal jugular valve may play a role in the pathogenesis of TGA. Paradoxical embolism due to PFO as a cause of TGA is not confirmed in our study. TGA patients have fewer vascular risk factors than TIA patients. ACUV detected jugular valve incompetence in 72.9% TGA, 35.7% TIA and 39.5% controls (TGA vs. No statistical difference was found between the 3 groups with regard to PFO. ![]() TGA patients and controls showed a lower prevalence for vascular risk factors than TIA patients. Retrograde jugular venous flow was tested with air contrast ultrasound venography (ACUV). Transient global amnesia Sudden, duration hours No recall of events, no loss of personal identity, repetitive questioning, no loss of consciousness Syncope Sudden Nonfocal symptoms, loss of consciousness Delirium, eg. PFO was studied by contrast transcranial duplex sonography. The aim of this study was to identify potential risk factors for TGA, vascular risk factors, the role of patent foramen ovale (PFO) and of retrograde jugular venous flow.ġ38 subjects entered the study, including 48 patients with TGA, 42 age-matched patients with transient ischaemic attack (TIA) and 48 controls. 10.1002/pds.The aetiology of transient global amnesia (TGA) is still unknown. Magnetic resonance of the brain including diffusionweighted imaging of patients with transient global amnesia revealed the presence of punctate hyperintense signal abnormalities in the hippocampus. Quantitative Signal Detection Using Spontaneous ADR Reporting: Quantitative Signal Detection. The main clinical feature of transient global amnesia (TGA) is an acute anterograde memory disturbance that resolves within 24 h. Transient global amnesia is a benign syndrome characterized by a sudden onset loss of anterograde amnesia with full recovery. Transient Global Amnesia: Functional Anatomy and Clinical Implications. Selective Affection of Hippocampal CA-1 Neurons in Patients with Transient Global Amnesia without Long-Term Sequelae. Actualité - Point de situation sur la surveillance des vaccins contre la COVID-19 - Période du au - ANSM. The identification of this trigger of TGA may help the clinician in his etiological research.ĬOVID-19 vaccines adverse drug reaction clinical epidemiology pharmacology transient global amnesia.Ĭopyright © 2022 Merino, Gérard, Van Obberghen, Ben Othman, Ettore, Giordana, Viard, Rocher, Destere, Benoit and Drici.ĪNSM (2021). In rare cases, TIA can cause memory loss. These attacks are often early warning signs of a stroke, however. Because the blood supply is restored quickly, brain tissue is not permanently damaged. Yet, numerous confounding factors cannot be tackled with this approach, and causality cannot be ascertained. A transient ischemic attack (TIA) is a brief episode during which parts of the brain do not receive enough blood. Cerebrovascular, inflammatory, or migrainous mechanisms may underlie this association. Our analysis of COVID-19 vaccines-related TGA reports shows significant disproportionality. With an IC025 > 0, COVID-19 vaccines showed a significant ROR (5.1 95%CI 4.4-6.0). Of all TGA cases, 289 were associated with a COVID-19 vaccine, representing the most frequent association. A positive lower end of the 95% CI of the IC (IC025) is used to statistically detect a signal. Disproportionality analysis relied on the Reporting Odds Ratio (ROR) with its 95% Confidence Interval (CI) and the Information Component (IC). ![]() We queried the World Health Organization VigiBase ® for all reports of "Transient global amnesia", up to 6 December 2021. We aimed to investigate the potential link of TGA with COVID-19 vaccines. TGA is characterized by sudden onset of anterograde amnesia with preservation of other cognitive functions and resolution within 24 h. As their safety continues to be monitored, cases of transient global amnesia (TGA) following mRNA vaccination with elasomeran have been reported. Coronavirus disease 2019 (COVID-19) spread rapidly, resulting in a global pandemic for which vaccines were quickly developed. ![]()
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